Sarah Silverman
Self
Nathan Barnatt
Homeless Man (segment "Lisa")
Lauren Lapkus
Girl 5 (segment "Lisa")
John C. Reilly
Father (segment "Ham")
Laura Silverman
Self (segment "Knickers")
Seth Rogen
Officer Durand (segment "Knickers")
Jade Catta-Preta
Mother (segment "Lisa")
Natasha Leggero
Girl 2 (segment "Lisa")
Shelby Fero
Girl 1 (segment "Lisa")
Nathan Fielder
Self (segment "Retro Video Arcade")
David Dineen-Porter
Self (segment "Retro Video Arcade")
Kyle Dunnigan
Self
Michael Daniel Cassady
Self (segment "Lisa")
Brett Gelman
Self
Emily Maya Mills
Girl 6 (segment "Lisa")
Nick Rutherford
Father (segment "Lisa")
Rob Schrab
Self
Paul Rust
Self (segment "Lisa")
Stoney Sharp
Self
Armen Weitzman
Mailman
Kulap Vilaysack
Girl 3 (segment "Lisa")
Eric Wareheim
Self
Harris Wittels
Scientist 1 (segment "CCDF")
Charlyne Yi
Self
Tig Notaro
Girl 4 (segment "Lisa")
Todd Glass
Self
Grace Helbig
Bride 5 (segment "Absorption")
2 Chainz
Self (segment "Absorption")
Casey Ford Alexander
Bad Guy 2 (segment "CCDF")
Jack Bornoff
Tomato Man (segment "Ham")
Hailey Boyle
Cashier (segment "Knickers")
Aaron Chrenen
Cooper (segment "Ginger Orphan Playhouse") (voice)
Larry A. Davies
Lloyd (segment "Absorption")
Greg Davis Jr.
Groom 2 (segment "Absorption")
Donna DuBain
Madame Trinkett (segment "Ginger Orphan Playhouse") (voice)
Trevor Eyster
Bad Guy 1 (segment "CCDF")
Malinda Farrington
Malinda (segment "Ham")
Kate Freund
Prostitute (segment "CCDF")
David Garcia
Bad Guy 3 (segment "CCDF")
Cyrus Ghahremani
Self
Hannah Hart
Bride 4 (segment "Absorption")
Deloris Heard
Customer (segment "Knickers")
Pamela Immel
Pamela (segment "Ham")
Zack Kennedy
Band Member 4 (segment "Absorption")
Keegan-Michael Key
Self (segment "Absorption")
Ben Lepley
Vacuum Salesman (segment "Ginger Orphan Playhouse") (voice)
Catherine Lydon
Cashier (segment "Ham")
Rasika Mathur
Bride 3 (segment "Absorption")
Kyle Pacek
Son (segment "Ham")
Sandeep Parikh
Groom 3 (segment "Absorption")
Jordan Peele
Self (segment "Absorption")
Issa Rae
Bride 2 (segment "Absorption")
Ron Ransen
Band Member 1 (segment "Absorption")
Mike Relm
Self
Willy Roberts
Taco Truck Worker (segment "CCDF")
Chase Stewart
Son (segment "Lisa")
Mark Taormino
Band Member 2 (segment "Absorption")
Brittani Taylor
Bride 1 (segment "Absorption")
Aono Tetsuji
Bad Guy 4 (segment "CCDF")
James Trenton
James (segment "Ham")
Jack Vale
Groom 1 (segment "Absorption")
